Genetic diversity of VAR2CSA ID1-DBL2Xb in worldwide Plasmodium falciparum populations: impact on vaccine design for placental malaria.
Identifieur interne : 003920 ( Main/Exploration ); précédent : 003919; suivant : 003921Genetic diversity of VAR2CSA ID1-DBL2Xb in worldwide Plasmodium falciparum populations: impact on vaccine design for placental malaria.
Auteurs : Bita Bordbar [France] ; Nicaise Tuikue Ndam [Bénin] ; Emmanuelle Renard [France] ; Sayeh Jafari-Guemouri [France] ; Livingstone Tavul [Papouasie-Nouvelle-Guinée] ; Charlie Jennison [Australie] ; Sédami Gnidehou [France] ; Rachida Tahar [France] ; Dionicia Gamboa [Pérou] ; Jorge Bendezu [Pérou] ; Didier Menard [Cambodge] ; Alyssa E. Barry [Australie] ; Philippe Deloron [France] ; Audrey Sabbagh [France]Source :
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [ 1567-7257 ] ; 2014.
Descripteurs français
- KwdFr :
- ADN des protozoaires (génétique), Adolescent, Adulte, Analyse de séquence d'ADN, Antigènes de protozoaire (génétique), Antigènes de protozoaire (immunologie), Complications parasitaires de la grossesse (immunologie), Complications parasitaires de la grossesse (parasitologie), Femelle, Fréquence d'allèle, Grossesse, Humains, Jeune adulte, Paludisme à Plasmodium falciparum (immunologie), Paludisme à Plasmodium falciparum (parasitologie), Paludisme à Plasmodium falciparum (épidémiologie), Phylogéographie, Placenta (immunologie), Placenta (parasitologie), Plasmodium falciparum (), Plasmodium falciparum (immunologie), Plasmodium falciparum (isolement et purification), Plasmodium falciparum (métabolisme), Vaccins antiviraux (génétique), Vaccins antiviraux (immunologie), Variation des antigènes (immunologie), Variation génétique.
- MESH :
- génétique : ADN des protozoaires, Antigènes de protozoaire, Vaccins antiviraux.
- immunologie : Antigènes de protozoaire, Complications parasitaires de la grossesse, Paludisme à Plasmodium falciparum, Placenta, Plasmodium falciparum, Vaccins antiviraux, Variation des antigènes.
- isolement et purification : Plasmodium falciparum.
- métabolisme : Plasmodium falciparum.
- parasitologie : Complications parasitaires de la grossesse, Paludisme à Plasmodium falciparum, Placenta.
- épidémiologie : Paludisme à Plasmodium falciparum.
- Adolescent, Adulte, Analyse de séquence d'ADN, Femelle, Fréquence d'allèle, Grossesse, Humains, Jeune adulte, Phylogéographie, Plasmodium falciparum, Variation génétique.
English descriptors
- KwdEn :
- Adolescent, Adult, Antigenic Variation (immunology), Antigens, Protozoan (genetics), Antigens, Protozoan (immunology), DNA, Protozoan (genetics), Female, Gene Frequency, Genetic Variation, Humans, Malaria, Falciparum (epidemiology), Malaria, Falciparum (immunology), Malaria, Falciparum (parasitology), Phylogeography, Placenta (immunology), Placenta (parasitology), Plasmodium falciparum (classification), Plasmodium falciparum (immunology), Plasmodium falciparum (isolation & purification), Plasmodium falciparum (metabolism), Pregnancy, Pregnancy Complications, Parasitic (immunology), Pregnancy Complications, Parasitic (parasitology), Sequence Analysis, DNA, Viral Vaccines (genetics), Viral Vaccines (immunology), Young Adult.
- MESH :
- chemical , genetics : Antigens, Protozoan, DNA, Protozoan, Viral Vaccines.
- classification : Plasmodium falciparum.
- epidemiology : Malaria, Falciparum.
- immunology : Antigenic Variation, Antigens, Protozoan, Malaria, Falciparum, Placenta, Plasmodium falciparum, Pregnancy Complications, Parasitic, Viral Vaccines.
- isolation & purification : Plasmodium falciparum.
- metabolism : Plasmodium falciparum.
- parasitology : Malaria, Falciparum, Placenta, Pregnancy Complications, Parasitic.
- Adolescent, Adult, Female, Gene Frequency, Genetic Variation, Humans, Phylogeography, Pregnancy, Sequence Analysis, DNA, Young Adult.
Abstract
In placental malaria (PM), sequestration of infected erythrocytes in the placenta is mediated by an interaction between VAR2CSA, a Plasmodium falciparum protein expressed on erythrocytes, and chondroitin sulfate A (CSA) on syncytiotrophoblasts. Recent works have identified ID1-DBL2Xb as the minimal CSA-binding region within VAR2CSA able to induce strong protective immunity, making it the leading candidate for the development of a vaccine against PM. Assessing the existence of population differences in the distribution of ID1-DBL2Xb polymorphisms is of paramount importance to determine whether geographic diversity must be considered when designing a candidate vaccine based on this fragment. In this study, we examined patterns of sequence variation of ID1-DBL2Xb in a large collection of P. falciparum field isolates (n=247) from different malaria-endemic areas, including Africa (Benin, Senegal, Cameroon and Madagascar), Asia (Cambodia), Oceania (Papua New Guinea), and Latin America (Peru). Detection of variants and estimation of their allele frequencies were performed using next-generation sequencing of DNA pools. A considerable amount of variation was detected along the whole gene segment, suggesting that several allelic variants may need to be included in a candidate vaccine to achieve broad population coverage. However, most sequence variants were common and extensively shared among worldwide parasite populations, demonstrating long term persistence of those polymorphisms, probably maintained through balancing selection. Therefore, a vaccine mixture including such stable antigen variants will be putatively applicable and efficacious in all world regions where malaria occurs. Despite similarity in ID1-DBL2Xb allele repertoire across geographic areas, several peaks of strong population differentiation were observed at specific polymorphic loci, pointing out putative targets of humoral immunity subject to positive immune selection.
DOI: 10.1016/j.meegid.2014.04.010
PubMed: 24768682
Affiliations:
- Australie, Bénin, Cambodge, France, Papouasie-Nouvelle-Guinée, Pérou
- Victoria (État), Île-de-France
- Melbourne, Paris
- Université Paris-Descartes
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Le document en format XML
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Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris, France; Centre d'Étude et de Recherche sur le Paludisme Associé à la Grossesse et à l'Enfance (CERPAGE), Cotonou, Benin.</nlm:affiliation><country xml:lang="fr">Bénin</country><wicri:regionArea>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris, France; Centre d'Étude et de Recherche sur le Paludisme Associé à la Grossesse et à l'Enfance (CERPAGE), Cotonou</wicri:regionArea><orgName type="university">Université Paris-Descartes</orgName><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Renard, Emmanuelle" sort="Renard, Emmanuelle" uniqKey="Renard E" first="Emmanuelle" last="Renard">Emmanuelle Renard</name><affiliation wicri:level="4"><nlm:affiliation>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; 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Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Tahar, Rachida" sort="Tahar, Rachida" uniqKey="Tahar R" first="Rachida" last="Tahar">Rachida Tahar</name><affiliation wicri:level="4"><nlm:affiliation>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; 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Barry</name><affiliation wicri:level="3"><nlm:affiliation>Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Deloron, Philippe" sort="Deloron, Philippe" uniqKey="Deloron P" first="Philippe" last="Deloron">Philippe Deloron</name><affiliation wicri:level="4"><nlm:affiliation>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Sabbagh, Audrey" sort="Sabbagh, Audrey" uniqKey="Sabbagh A" first="Audrey" last="Sabbagh">Audrey Sabbagh</name><affiliation wicri:level="4"><nlm:affiliation>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris, France. Electronic address: audrey.sabbagh@ird.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24768682</idno><idno type="pmid">24768682</idno><idno type="doi">10.1016/j.meegid.2014.04.010</idno><idno type="wicri:Area/PubMed/Corpus">003671</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003671</idno><idno type="wicri:Area/PubMed/Curation">003558</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003558</idno><idno type="wicri:Area/PubMed/Checkpoint">003558</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003558</idno><idno type="wicri:Area/Ncbi/Merge">001991</idno><idno type="wicri:Area/Ncbi/Curation">001991</idno><idno type="wicri:Area/Ncbi/Checkpoint">001991</idno><idno type="wicri:Area/Main/Merge">003956</idno><idno type="wicri:Area/Main/Curation">003920</idno><idno type="wicri:Area/Main/Exploration">003920</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic diversity of VAR2CSA ID1-DBL2Xb in worldwide Plasmodium falciparum populations: impact on vaccine design for placental malaria.</title><author><name sortKey="Bordbar, Bita" sort="Bordbar, Bita" uniqKey="Bordbar B" first="Bita" last="Bordbar">Bita Bordbar</name><affiliation wicri:level="4"><nlm:affiliation>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Tuikue Ndam, Nicaise" sort="Tuikue Ndam, Nicaise" uniqKey="Tuikue Ndam N" first="Nicaise" last="Tuikue Ndam">Nicaise Tuikue Ndam</name><affiliation wicri:level="4"><nlm:affiliation>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris, France; Centre d'Étude et de Recherche sur le Paludisme Associé à la Grossesse et à l'Enfance (CERPAGE), Cotonou, Benin.</nlm:affiliation><country xml:lang="fr">Bénin</country><wicri:regionArea>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris, France; Centre d'Étude et de Recherche sur le Paludisme Associé à la Grossesse et à l'Enfance (CERPAGE), Cotonou</wicri:regionArea><orgName type="university">Université Paris-Descartes</orgName><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Renard, Emmanuelle" sort="Renard, Emmanuelle" uniqKey="Renard E" first="Emmanuelle" last="Renard">Emmanuelle Renard</name><affiliation wicri:level="4"><nlm:affiliation>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Jafari Guemouri, Sayeh" sort="Jafari Guemouri, Sayeh" uniqKey="Jafari Guemouri S" first="Sayeh" last="Jafari-Guemouri">Sayeh Jafari-Guemouri</name><affiliation wicri:level="4"><nlm:affiliation>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Tavul, Livingstone" sort="Tavul, Livingstone" uniqKey="Tavul L" first="Livingstone" last="Tavul">Livingstone Tavul</name><affiliation wicri:level="1"><nlm:affiliation>Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea.</nlm:affiliation><country xml:lang="fr">Papouasie-Nouvelle-Guinée</country><wicri:regionArea>Papua New Guinea Institute of Medical Research, Madang</wicri:regionArea><wicri:noRegion>Madang</wicri:noRegion></affiliation></author><author><name sortKey="Jennison, Charlie" sort="Jennison, Charlie" uniqKey="Jennison C" first="Charlie" last="Jennison">Charlie Jennison</name><affiliation wicri:level="3"><nlm:affiliation>Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Gnidehou, Sedami" sort="Gnidehou, Sedami" uniqKey="Gnidehou S" first="Sédami" last="Gnidehou">Sédami Gnidehou</name><affiliation wicri:level="4"><nlm:affiliation>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Tahar, Rachida" sort="Tahar, Rachida" uniqKey="Tahar R" first="Rachida" last="Tahar">Rachida Tahar</name><affiliation wicri:level="4"><nlm:affiliation>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Gamboa, Dionicia" sort="Gamboa, Dionicia" uniqKey="Gamboa D" first="Dionicia" last="Gamboa">Dionicia Gamboa</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Medicina Tropical "Alexander Von Humboldt", Universidad Peruana Cayetano Heredia, Lima, Peru.</nlm:affiliation><country xml:lang="fr">Pérou</country><wicri:regionArea>Instituto de Medicina Tropical "Alexander Von Humboldt", Universidad Peruana Cayetano Heredia, Lima</wicri:regionArea><wicri:noRegion>Lima</wicri:noRegion></affiliation></author><author><name sortKey="Bendezu, Jorge" sort="Bendezu, Jorge" uniqKey="Bendezu J" first="Jorge" last="Bendezu">Jorge Bendezu</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Medicina Tropical "Alexander Von Humboldt", Universidad Peruana Cayetano Heredia, Lima, Peru.</nlm:affiliation><country xml:lang="fr">Pérou</country><wicri:regionArea>Instituto de Medicina Tropical "Alexander Von Humboldt", Universidad Peruana Cayetano Heredia, Lima</wicri:regionArea><wicri:noRegion>Lima</wicri:noRegion></affiliation></author><author><name sortKey="Menard, Didier" sort="Menard, Didier" uniqKey="Menard D" first="Didier" last="Menard">Didier Menard</name><affiliation wicri:level="1"><nlm:affiliation>Unité d'Epidémiologie Moléculaire, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.</nlm:affiliation><country xml:lang="fr">Cambodge</country><wicri:regionArea>Unité d'Epidémiologie Moléculaire, Institut Pasteur du Cambodge, Phnom Penh</wicri:regionArea><wicri:noRegion>Phnom Penh</wicri:noRegion></affiliation></author><author><name sortKey="Barry, Alyssa E" sort="Barry, Alyssa E" uniqKey="Barry A" first="Alyssa E" last="Barry">Alyssa E. Barry</name><affiliation wicri:level="3"><nlm:affiliation>Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Deloron, Philippe" sort="Deloron, Philippe" uniqKey="Deloron P" first="Philippe" last="Deloron">Philippe Deloron</name><affiliation wicri:level="4"><nlm:affiliation>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Sabbagh, Audrey" sort="Sabbagh, Audrey" uniqKey="Sabbagh A" first="Audrey" last="Sabbagh">Audrey Sabbagh</name><affiliation wicri:level="4"><nlm:affiliation>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris, France. Electronic address: audrey.sabbagh@ird.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>PRES Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Institut de Recherche Pour le Développement (IRD), UMR216 Mère et enfant face aux infections tropicales, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author></analytic><series><title level="j">Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases</title><idno type="eISSN">1567-7257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Antigenic Variation (immunology)</term><term>Antigens, Protozoan (genetics)</term><term>Antigens, Protozoan (immunology)</term><term>DNA, Protozoan (genetics)</term><term>Female</term><term>Gene Frequency</term><term>Genetic Variation</term><term>Humans</term><term>Malaria, Falciparum (epidemiology)</term><term>Malaria, Falciparum (immunology)</term><term>Malaria, Falciparum (parasitology)</term><term>Phylogeography</term><term>Placenta (immunology)</term><term>Placenta (parasitology)</term><term>Plasmodium falciparum (classification)</term><term>Plasmodium falciparum (immunology)</term><term>Plasmodium falciparum (isolation & purification)</term><term>Plasmodium falciparum (metabolism)</term><term>Pregnancy</term><term>Pregnancy Complications, Parasitic (immunology)</term><term>Pregnancy Complications, Parasitic (parasitology)</term><term>Sequence Analysis, DNA</term><term>Viral Vaccines (genetics)</term><term>Viral Vaccines (immunology)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN des protozoaires (génétique)</term><term>Adolescent</term><term>Adulte</term><term>Analyse de séquence d'ADN</term><term>Antigènes de protozoaire (génétique)</term><term>Antigènes de protozoaire (immunologie)</term><term>Complications parasitaires de la grossesse (immunologie)</term><term>Complications parasitaires de la grossesse (parasitologie)</term><term>Femelle</term><term>Fréquence d'allèle</term><term>Grossesse</term><term>Humains</term><term>Jeune adulte</term><term>Paludisme à Plasmodium falciparum (immunologie)</term><term>Paludisme à Plasmodium falciparum (parasitologie)</term><term>Paludisme à Plasmodium falciparum (épidémiologie)</term><term>Phylogéographie</term><term>Placenta (immunologie)</term><term>Placenta (parasitologie)</term><term>Plasmodium falciparum ()</term><term>Plasmodium falciparum (immunologie)</term><term>Plasmodium falciparum (isolement et purification)</term><term>Plasmodium falciparum (métabolisme)</term><term>Vaccins antiviraux (génétique)</term><term>Vaccins antiviraux (immunologie)</term><term>Variation des antigènes (immunologie)</term><term>Variation génétique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Protozoan</term><term>DNA, Protozoan</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Malaria, Falciparum</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN des protozoaires</term><term>Antigènes de protozoaire</term><term>Vaccins antiviraux</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes de protozoaire</term><term>Complications parasitaires de la grossesse</term><term>Paludisme à Plasmodium falciparum</term><term>Placenta</term><term>Plasmodium falciparum</term><term>Vaccins antiviraux</term><term>Variation des antigènes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Antigenic Variation</term><term>Antigens, Protozoan</term><term>Malaria, Falciparum</term><term>Placenta</term><term>Plasmodium falciparum</term><term>Pregnancy Complications, Parasitic</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Complications parasitaires de la grossesse</term><term>Paludisme à Plasmodium falciparum</term><term>Placenta</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Malaria, Falciparum</term><term>Placenta</term><term>Pregnancy Complications, Parasitic</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Paludisme à Plasmodium falciparum</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Female</term><term>Gene Frequency</term><term>Genetic Variation</term><term>Humans</term><term>Phylogeography</term><term>Pregnancy</term><term>Sequence Analysis, DNA</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Analyse de séquence d'ADN</term><term>Femelle</term><term>Fréquence d'allèle</term><term>Grossesse</term><term>Humains</term><term>Jeune adulte</term><term>Phylogéographie</term><term>Plasmodium falciparum</term><term>Variation génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In placental malaria (PM), sequestration of infected erythrocytes in the placenta is mediated by an interaction between VAR2CSA, a Plasmodium falciparum protein expressed on erythrocytes, and chondroitin sulfate A (CSA) on syncytiotrophoblasts. Recent works have identified ID1-DBL2Xb as the minimal CSA-binding region within VAR2CSA able to induce strong protective immunity, making it the leading candidate for the development of a vaccine against PM. Assessing the existence of population differences in the distribution of ID1-DBL2Xb polymorphisms is of paramount importance to determine whether geographic diversity must be considered when designing a candidate vaccine based on this fragment. In this study, we examined patterns of sequence variation of ID1-DBL2Xb in a large collection of P. falciparum field isolates (n=247) from different malaria-endemic areas, including Africa (Benin, Senegal, Cameroon and Madagascar), Asia (Cambodia), Oceania (Papua New Guinea), and Latin America (Peru). Detection of variants and estimation of their allele frequencies were performed using next-generation sequencing of DNA pools. A considerable amount of variation was detected along the whole gene segment, suggesting that several allelic variants may need to be included in a candidate vaccine to achieve broad population coverage. However, most sequence variants were common and extensively shared among worldwide parasite populations, demonstrating long term persistence of those polymorphisms, probably maintained through balancing selection. Therefore, a vaccine mixture including such stable antigen variants will be putatively applicable and efficacious in all world regions where malaria occurs. Despite similarity in ID1-DBL2Xb allele repertoire across geographic areas, several peaks of strong population differentiation were observed at specific polymorphic loci, pointing out putative targets of humoral immunity subject to positive immune selection.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Bénin</li><li>Cambodge</li><li>France</li><li>Papouasie-Nouvelle-Guinée</li><li>Pérou</li></country><region><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Melbourne</li><li>Paris</li></settlement><orgName><li>Université Paris-Descartes</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Bordbar, Bita" sort="Bordbar, Bita" uniqKey="Bordbar B" first="Bita" last="Bordbar">Bita Bordbar</name></region><name sortKey="Deloron, Philippe" sort="Deloron, Philippe" uniqKey="Deloron P" first="Philippe" last="Deloron">Philippe Deloron</name><name sortKey="Gnidehou, Sedami" sort="Gnidehou, Sedami" uniqKey="Gnidehou S" first="Sédami" last="Gnidehou">Sédami Gnidehou</name><name sortKey="Jafari Guemouri, Sayeh" sort="Jafari Guemouri, Sayeh" uniqKey="Jafari Guemouri S" first="Sayeh" last="Jafari-Guemouri">Sayeh Jafari-Guemouri</name><name sortKey="Renard, Emmanuelle" sort="Renard, Emmanuelle" uniqKey="Renard E" first="Emmanuelle" last="Renard">Emmanuelle Renard</name><name sortKey="Sabbagh, Audrey" sort="Sabbagh, Audrey" uniqKey="Sabbagh A" first="Audrey" last="Sabbagh">Audrey Sabbagh</name><name sortKey="Tahar, Rachida" sort="Tahar, Rachida" uniqKey="Tahar R" first="Rachida" last="Tahar">Rachida Tahar</name></country><country name="Bénin"><region name="Île-de-France"><name sortKey="Tuikue Ndam, Nicaise" sort="Tuikue Ndam, Nicaise" uniqKey="Tuikue Ndam N" first="Nicaise" last="Tuikue Ndam">Nicaise Tuikue Ndam</name></region></country><country name="Papouasie-Nouvelle-Guinée"><noRegion><name sortKey="Tavul, Livingstone" sort="Tavul, Livingstone" uniqKey="Tavul L" first="Livingstone" last="Tavul">Livingstone Tavul</name></noRegion></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Jennison, Charlie" sort="Jennison, Charlie" uniqKey="Jennison C" first="Charlie" last="Jennison">Charlie Jennison</name></region><name sortKey="Barry, Alyssa E" sort="Barry, Alyssa E" uniqKey="Barry A" first="Alyssa E" last="Barry">Alyssa E. Barry</name></country><country name="Pérou"><noRegion><name sortKey="Gamboa, Dionicia" sort="Gamboa, Dionicia" uniqKey="Gamboa D" first="Dionicia" last="Gamboa">Dionicia Gamboa</name></noRegion><name sortKey="Bendezu, Jorge" sort="Bendezu, Jorge" uniqKey="Bendezu J" first="Jorge" last="Bendezu">Jorge Bendezu</name></country><country name="Cambodge"><noRegion><name sortKey="Menard, Didier" sort="Menard, Didier" uniqKey="Menard D" first="Didier" last="Menard">Didier Menard</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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